Cover Picture: Eur. J. Immunol. 10/08

J Immunol

Retinoic acid (RA), a well-known vitamin A metabolite, mediates inhibition of the IL-6driven induction of proinflammatory Th17 cells and promotes anti-inflammatory regulatory T cell generation in the presence of TGF-beta, which is mainly regulated by dendritic cells. To directly address the role of RA in Th17/regulatory T cell generation in vivo, we generated vitamin A-deficient (VAD) mice by c...

Cover Picture.

Mucosal Immunol

Loss of CD4(+) T cells in the gut is necessary but not sufficient to cause AIDS in animal models, raising the possibility that a differential loss of CD4(+) T-cell subtypes may be important. We found that CD4(+) T cells that produce interleukin (IL)-17, a recently identified lineage of effector CD4(+) T-helper cells, are infected by SIV(mac251)in vitro and in vivo, and are found at lower freque...

Dmd057018 1008..1015

The glycogen synthase kinase-3 inhibitor LY2090314 specifically impaired CYP2B6 activity during in vitro evaluation of cytochrome P450 (P450) enzyme induction in human hepatocytes. CYP2B6 catalytic activity was significantly decreased following 3-day incubation with 0.1–10 mM LY2090314, on average by 64.3%6 5.0% at 10 mM. These levels of LY2090314 exposure were not cytotoxic to hepatocytes and ...

Cover Picture Story: Experiments with Modular State Spaces

The main analysis techniques for critical systems use state space exploration. However, one is often quickly limited by the so-called state space explosion problem, even if the systems models are relatively small. Several methods have been proposed to tackle this problem in order to get a manageable state space. One of these takes advantage of the modular structure of the model in order to buil...